Sunday (July 7, 2024)


Opening Ceremony (Room A)

Welcome Remarks

Xinxin Ding
Jiri Hudecek
Petr Pavek

17:45 – 18:10

Opening keynote presentation

Bettie Sue Masters Duke University, USA

A Sojourn Down MDO Memory Lane

18:10 – 18:35

Opening Symposium

In silico and PBPK(D) modeling of drug metabolism

Amin Rostami-Hodjegan

18:35 – 19:25

Opening Symposium

In vitro and in silico systems for prediction of drug metabolism and toxicity/ In vitro to in vivo extrapolation (IVIVE) in drug development

Matthew A. Cerny - A Comparison of In Vitro and In Vivo Metabolite Profiles – How Predictive are our In Vitro Assays?

Carl Petersson - Addressing the challenge of low clearance drug candidates; solutions for the extrapolation from in vitro systems and reaction phenotyping.

19:30Welcome drink

Monday (July 8, 2024)

Plenary lecture (Room A)
8:30 - 9:00

F. Peter Guengerich
Vanderbilt University, Nashville, Tennessee
Mechanisms of Complex Cytochrome P450 Reactions–New Insights

Concurrent Symposium 1 (Room A)
9:00 - 10:30

Novel structural insights and functions of cytochromes P450

Elizabeth M. J. Gillam
Emily E. Scott

Elizabeth M. J. Gillam - Old folds can learn new tricks: what evolution can tell us about innovation in P450s

John C. Hackett - Cytochrome P450 19A1 dynamics and ligand recognition in membranes

Stephen Bell - Structural insights into cytochrome P450 enzymes from in crystallo reactions and variable-temperature X-ray crystallography

Thomas Pochapsky, Kurt Harris, Nathan Wong, Liam Flynn, Alaina M. Richard,
and Emily E. Scott. - Selective binding and inhibition of CYPs by isonitriles

Concurrent Symposium 2 (Room B)
9:00 - 10:30

Transcriptional and signaling-based regulation of drug metabolism

Oliver Burk
Taoseng Chen

Taoseng Chen - Selective modulation of the promiscuous and dynamic PXR and CYP3A4/5

William Bourguet - Structural insights into ligand binding affinity, specificity and promiscuity in the aryl hydrocarbon receptor

Thales Kronenberger - Computational study of conformational changes in nuclear receptors upon ligand binding

Jinjing Chen - Hammerhead-type FXR agonists induce an enhancer RNA Fincor: Friend or Foe in metabolic liver disease? (shorter talk)

10:30 - 11:00
Coffee break (30 min)

Concurrent Symposium 3 (Room A)
11:00 - 12:30

Mechanisms and dynamics of P450 and other xenobiotic-metabolizing enzymes

Jed N. Lampe
Emre M. Isin

J. N. Lampe - Molecular dynamics simulations reveal a conserved role for the F/G loop domain in cytochrome P450 CYP3A family multiple ligand binding

Emre M. Isin - Unusual Biotransformation Reactions: Expecting the Unexpected

James De Voss - Mechanism of P450 catalysed dehydrogenation in the model bacterial P450 CYP199A4

Rebecca C. Wade - Multiscale molecular dynamics simulations to investigate how cytochrome P450 conformational plasticity affects its interactions and function

Concurrent Symposium 4 (Room B)
11:00 - 12:30

Nuclear Xenobiotic Receptors: PXR and CAR in metabolism and diseases

Jukka Hakkola
Petr Pavek

Jukka Hakkola - PXR activation-induced effects on metabolic health

Petr Pavek - Novel PXR/CAR ligands as an intervention in metabolic diseases

Oliver Burk - PXR-dependent modulation of hepatic sphingolipid and phospholipid metabolism

Itsuki Yokoseki - BRD9, a chromatin remodeling factor, negatively regulates PPARα-mediated transcription of CPT1A to attenuated lipid metabolism

12:20 - 13:30
Lunch, Exhibit Hall Hours

13:30 - 14:30
Poster Viewing, Poster Presentation Session

Concurrent Symposium 5 (Room A)
14:30 - 15:50

CYPs in endogenous metabolism of lipids and steroids

Irina Pikuleva
Amit V. Pandey

Irina Pikuleva - CYP46A1 in the Brain: It is Not Just Cholesterol Elimination

Amit V. Pandey - Regulation of Steroid Metabolism by Human Genetic Variations in the Redox Partners of Cytochrome P450 proteins

Richard J. Auchus - Why is P450 11B2 an aldosterone synthase and P450 11B1 is not?

Concurrent Symposium 6 (Room B)
14:30 - 15:50

Drug metabolizing enzymes, transporters, and nuclear receptors as therapeutic targets

Hongbing Wang
Huichang Bi

Hongbing Wang - Activation of CAR and Nrf2 in cyclophosphamide- and doxorubicin-based chemotherapy

Huichang Bi - The novel role of PXR in liver diseases and beyond

Kouichi Yoshinari - Cytochrome P450 inhibition, AHR activation, and liver injury

15:50 - 16:20
Coffee break (30 min)

16:20 - 16:40
Commercial presentation
Miroslav Kandar - Mattek Life Sciences – reproducible in vitro reconstructed
human tissues as an alternative to testing on animals

Concurrent Symposium 7 (Room A)
16:40 - 18:00

Structure and functions of non-cytochrome P450 enzymes and phase II conjugation enzymes in drug metabolism

Miki Nakajima
Wen Xie

Tatsuki Fukami - Novel characteristics of non-P450 oxidases unraveled from functional analyses

Wen Xie - Sulfation in Drug-induced Liver Injury, the expected and unexpected

Sheila J. Sadeghi - Flavin-containing monooxygenases: polymorphic variants and their effect on drug metabolism

Concurrent Symposium 8 (Room B)
16:40 - 18:00

Importance of ncRNAs and lncRNAs in metabolism regulation and liver diseases

Baitang Ning
David Waxman

Baitang Ning - The importance of ncRNA and lncRNA in the regulation of metabolism and liver toxicity

David Waxman - Global analysis of hepatic lncRNA functions in liver disease: Cell type specificities, zonation patterns, hepatic intercellular communication, and gene regulatory networks deduced from single cell sequencing

Shogo Takahashi - The Hidden Regulators: Unveiling the Roles of Two CAR-Regulated lncRNAs in Liver Physiology Using Mouse Knockout Models

20:00 - 22:00
Panoramic Vltava River Cruise with Conference Dinner (not included in the reg. fee)

Tuesday (July 9, 2024)

Plenary lecture (Room A)
8:30 - 9:00
Magnus Ingelman-Sundberg
Department of Physiology and Pharmacology, Karolinska Institutet, Sweden
Enhancing Drug - Development Through Innovative 3D Liver Models

Concurrent Symposium 9 (Room A)
9:00 - 10:30

Pharmacogenomics of drug-metabolizing enzymes: clinical relevance and ethnic diversity

Magnus Ingelman-Sundberg
Rachel Tyndale

Todd C. Skaar - Discovery of rare ancestry-enriched variants that impact drug metabolism.

Rachel F. Tyndale - Big data to investigate the role of polygenic, structurally variable CYP2A6 in disease

Matthias Schwab - Innovation in cancer pharmacotherapy through integrative consideration of pharmacogenomics profiles

Christopher A. Reilly, Marysol Almestica-Roberts, and Flory L. Nkoy.
Differential metabolism of linoleic acid and cortisol by cytochrome P450 2C8*3 and 3A5*3 enzyme variants influences asthma symptom control in children (a shorter talk)

Concurrent Symposium 10 (Room B)
9:00 - 10:30

Novel animal models to predict drug metabolism and toxicity

Hiroshi Yamazaki

José E. Manautou

Hiroshi Yamazaki - Pharmacokinetic modeling for drugs using inactivated-P450 human hepatocytes after transplantation into immunodeficient mice

José E. Manautou - Deciphering the impact of hepatic Multidrug resistance protein 4 (Mrp4) in liver steatosis and metabolic syndrome pathogenesis

Mario Mezler - Analysis of the bile acid composition in a fibroblast growth factor 19-expressing liver-humanized mouse model and its use for CYP3A4-mediated drug-drug interaction studies

Grace Guo - Generation of Low-bile Acid Mouse Model to Decipher Roles of Individual Bile Acids in MASH Development (a shorter talk)

10:30 - 11:00
Coffee break (30 min)

Concurrent Symposium 11 (Room A)
11:00 - 12:20

Biomarkers for prediction of drug metabolism and toxicity

Ann Daly
Christopher Goldring

Ann Daly - Pharmacogenomics of drug-induced liver injury-metabolic and immunogenetic biomarkers

Christopher Goldring - Biomarkers for drug-induced liver injury and the TransBioLine study

Mikko Niemi - Circulating biomarkers for drug transporters

Concurrent Symposium 12 (Room B)
11:00 - 12:30

3D experimental models and organ-on-chips in drug metabolism

Volker M. Lauschke
Tore B. Stage

Volker M. Lauschke - Organotypic and microphysiological primary human tissue models for translational pharmacology

Jonathan Sexton - Personalized Liver Injury Risk Prediction: Patient-Derived Organoids on Chip

Masaru Koido - How can we translate findings from human genetic association studies?

Jasleen K. Sodhi - Hepatic 3D Liver Models and IVIVE

12:30 - 13:30
Lunch, Exhibit Hall Hours

13:30 - 14:30
Poster Viewing, Poster Presentation Session

Concurrent Symposium 13 (Room A)
14:30 - 15:50

Inflammatory regulation of cytochrome P450 enzymes and COVID-19

Kerry B. Goralski
Tore B. Stage

Kerry B. Goralski - COVID-19 and CYP3A4 drug metabolism interactions: A review of the evidence

Tore B. Stage - Translational aspects of drug metabolism during inflammation from clinical studies and 3D primary human hepatocytes

Gülsah Gabriel - Respiratory virus infection mediated dysregulation of sex hormone metabolism

Concurrent Symposium 14 (Room B)
14:30 - 15:50

Omics and single-cell-based technologies in the study of drug metabolism

Albert Braeuning
Damjana Rozman

Albert Braeuning - The use of proteomic approaches to analyze in vivo effects of phenobarbital in mice with humanized livers

Damjana Rozman - Targeted omics for innovative decision support systems: examples of COVID-19 and liver cancer

Celia P. Martinez-Jimenez - Unraveling Hepatocyte Heterogeneity: Implications for Drug Metabolism and Toxicity Under Metabolic Stress

15:50 - 16:20
Coffee break (30 min)

16:20 - 16:40 Commercial presentations

K. Yildirim - Empowering Microbiome-Drug Interaction Research: Innovative Tools from Promega

R. Xinxin Ding - Publishing your work in ASPET journals.

Concurrent Symposium 15 (Room A)
16:40 - 18:00

Interactions of microbiome on drug metabolism

Pavel Anzenbacher

Hyunyoung (Young) Jeong

Pavel Anzenbacher - Drug Metabolism and Gut Microbiome

Hyunyoung (Young) Jeong - Modulation of Drug-induced Hepatotoxicity by Gut Microbial Metabolite

Sridhar Mani - Intestinal Microbial metabolites, Nuclear Receptors, and Microbial Metabolite Mimicry: An Update

Concurrent Symposium 16 (Room B)
16:40 - 18:00

Oligonucleotide and peptide ADME

Xiaobo Zhong
Hongbin Yu

Hongbin Yu - Perspectives on ADME of therapeutic proteins

Aiming Yu - ADME of therapeutic RNAs

Sherouk Tawfik - Triple E challenges for better efficacy of siRNA therapeutics: targeted endocytosis, endosomal escape, and exocytosis

Organ Concert in Carolinum, medieval Hall of the Charles University

Wednesday (July 10, 2024)

Plenary lecture (Room A)
8:30 - 9:00

Emily E. Scott, Ph.D.
University of Michigan
Human microsomal and mitochondrial P450 interactions with substrates and redox partners

Concurrent Symposium 17 (Room A)
9:00 - 10:30

Intestinal and extrahepatic metabolizing enzymes in bioavailability and disposition

Xinxin Ding

Stefan Oswald

Xinxin Ding - Dissecting hepatic and extrahepatic contributions to xenobiotic metabolism using transgenic mouse models

Stefan Oswald - Intra-subject analysis of gene expression and protein abundance of major and minor drug metabolizing enzymes along the healthy human intestine

Joan Z. Zuo - Intestinal carboxylesterase mediated activation of irinotecan and its impact on herb-drug interactions

Bhagavatula Moorthy - Attenuation of polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis by omega 3-fatty acids in vivo (shorter talk)

Concurrent Symposium 18 (Room B)
9:00 - 10:30

Drug transporters and their impact on drug metabolism and disposition

Sibylle Neuhoff
Jean Terrier

Matus Sotak - Circadian regulation of transporter expression: Implications for drug disposition and translational challenges

Dirk Theile - The unequal perpetrator effects of rifampicin vs. rifabutin on P-glycoprotein and substrate drugs pharmacokinetics

Jean Terrier - Drug transporters and their impact on the pharmacokinetics of direct oral anticoagulants using PK modelling.

Sibylle Neuhoff/Matthew D. Harwood - PBPK modeling of endogenous biomarker to assess hepatic and renal transporter-mediated DDIs in healthy and disease

10:30 - 11:00
Coffee break (30 min)

11:00 - 12:00
Best Posters Awards and Best Poster Winner Presentations

Closing Ceremony
Closing Remarks
The upcoming 26th MDO meeting in Hong Kong

12:30 - 13:30
MATTEK Workshop (Room B)

Optional Visit to Prague Castle (not incl. in the registration fee)