Sunday (July 7, 2024)

15:00Registration starts

Opening Session

Welcome Remarks

Xinxin Ding
Jiri Hudecek
Petr Pavek

17:15 – 17:40

Opening keynote presentation

Bettie Sue Siler Masters Duke University, USA

A Sojourn Down MDO Memory Lane

17:40 – 18:30

Opening Symposium

In silico and PBPK(D) modeling of drug metabolism / Quantitative systems pharmacology (QSP)

Amin Rostami-Hochaghan

Thorsten Lehr

18:30 – 19:20

Opening Symposium

In vitro and in silico systems for prediction of drug metabolism and toxicity/ In vitro to in vivo extrapolation (IVIVE) in drug development

Matthew A. Cerny - A Comparison of In Vitro and In Vivo Metabolite Profiles – How Predictive are our In Vitro Assays?

Carl Petersson

19:30Welcome drink

Monday (July 8, 2024)

Plenary lecture
8:30 - 9:00

F. Peter Guengerich
Vanderbilt University, Nashville, Tennessee
Mechanisms of Complex Cytochrome P450 Reactions–New Insights

Concurrent Symposium 1
9:00 - 10:30

Novel structural insights and functions of cytochromes P450

Elizabeth M. J. Gillam
Emily E. Scott

Elizabeth M. J. Gillam - Old folds can learn new tricks: what evolution can tell us about innovation in P450s

John C. Hackett - Cytochrome P450 19A1 dynamics and ligand recognition in membranes

Stephen Bell - Structural insights into cytochrome P450 enzymes from in crystallo reactions and variable-temperature X-ray crystallography

Concurrent Symposium 2
9:00 - 10:30

Transcriptional and signaling-based regulation of drug metabolism

Oliver Burk
Taoseng Chen

Taoseng Chen - Selective modulation of the promiscuous and dynamic PXR and CYP3A4/5

William Bourguet - Structural insights into ligand binding affinity, specificity and promiscuity in the aryl hydrocarbon receptor

Thales Kronenberger - Computational study of conformational changes in nuclear receptors upon ligand binding

10:30 - 11:00
Coffee break (30 min)

Concurrent Symposium 3
11:00 - 12:30

Mechanisms and dynamics of P450 and other xenobiotic-metabolizing enzymes

Jed N. Lampe
Emre M. Isin

J. N. Lampe - Molecular dynamics simulations reveal a conserved role for the F/G loop domain in cytochrome P450 CYP3A family multiple ligand binding

Emre M. Isin - Unusual Biotransformation Reactions: Expecting the Unexpected

James De Voss - Mechanism of P450 catalysed dehydrogenation in the model bacterial P450 CYP199A4

Rebecca C. Wade - Multiscale molecular dynamics simulations to investigate how cytochrome P450 conformational plasticity affects its interactions and function

Concurrent Symposium 4
11:00 - 12:20

Nuclear Xenobiotic Receptors: PXR and CAR in metabolism and diseases

Jukka Hakkola
Petr Pavek

Jukka Hakkola - PXR activation-induced effects on metabolic health

Petr Pavek - Novel PXR/CAR ligands as an intervention in metabolic diseases

Oliver Burk - PXR-dependent modulation of hepatic sphingolipid and phospholipid metabolism

12:20 - 13:20
Lunch, Exhibit Hall Hours

13:20 - 14:20
Poster Viewing, Poster Presentation Session

Concurrent Symposium 5
14:20 - 15:40

CYPs in endogenous metabolism of lipids and steroids

Irina Pikuleva
Amit V. Pandey

Irina Pikuleva - CYP46A1 in the Brain: It is Not Just Cholesterol Elimination

Amit V. Pandey - Regulation of Steroid Metabolism by Human Genetic Variations in the Redox Partners of Cytochrome P450 proteins

Richard J. Auchus - Why is P450 11B2 an aldosterone synthase and P450 11B1 is not?

Concurrent Symposium 6
14:20 - 15:40

Drug metabolizing enzymes, transporters, and nuclear receptors as therapeutic targets

Hongbing Wang
Huichang Bi

Hongbing Wang - Activation of CAR and Nrf2 in cyclophosphamide- and doxorubicin-based chemotherapy

Huichang Bi - The novel role of PXR in liver diseases and beyond

Kouichi Yoshinari - Cytochrome P450 inhibition, AHR activation, and liver injury

15:40 - 16:10
Coffee break (30 min)

16:10 - 16:30
Commercial presentations

Concurrent Symposium 7
16:30 - 17:50

Structure and functions of non-cytochrome P450 enzymes and phase II conjugation enzymes in drug metabolism

Miki Nakajima
Wen Xie

Tatsuki Fukami - Novel characteristics of non-P450 oxidases unraveled from functional analyses

Wen Xie - Sulfation in Drug-induced Liver Injury, the expected and unexpected

Sheila J. Sadeghi - Flavin-containing monooxygenases: polymorphic variants and their effect on drug metabolism

Concurrent Symposium 8
16:30 - 17:50

Importance of ncRNAs and lncRNAs in metabolism regulation and liver diseases

Baitang Ning
David Waxman

Baitang Ning

David Waxman - Xenobiotic responsive hepatic long non-coding RNAs. Dysregulated expression, liver zonation, and intercellular communication in liver disease at the single cell level

Shogo Takahashi - The Hidden Regulators: Unveiling the Roles of Two CAR-Regulated lncRNAs in Liver Physiology Using Mouse Knockout Models

20:00 - 22:00
Panoramic Vltava River Cruise with Conference Dinner (not included in the reg. fee)

Tuesday (July 9, 2024)

Plenary lecture
8:30 - 9:00
Magnus Ingelman-Sundberg
Department of Physiology and Pharmacology, Karolinska Institutet, Sweden
Enhancing Drug - Development Through Innovative 3D Liver Models

Concurrent Symposium 9
9:00 - 10:30

Pharmacogenomics of drug-metabolizing enzymes: clinical relevance and ethnic diversity

Magnus Ingelman-Sundberg
Rachel Tyndale

Todd C. Skaar - Discovery and implementation of genomic predictors of drug response (tentative title)

Rachel F. Tyndale - Big data to investigate the role of polygenic, structurally variable CYP2A6 in disease

Matthias Schwab - Innovation in cancer pharmacotherapy through integrative consideration of pharmacogenomics profiles

Concurrent Symposium 10
9:00 - 10:30

Novel animal models to predict drug metabolism and toxicity

Hiroshi Yamazaki

José E. Manautou

Hiroshi Yamazaki - Pharmacokinetic modeling for drugs using inactivated-P450 human hepatocytes after transplantation into immunodeficient mice

José E. Manautou - Deciphering the impact of hepatic Multidrug resistance protein 4 (Mrp4) in liver steatosis and metabolic syndrome pathogenesis

Mario Mezler - Analysis of the bile acid composition in a fibroblast growth factor 19-expressing liver-humanized mouse model and its use for CYP3A4-mediated drug-drug interaction studies

10:30 - 11:00
Coffee break (30 min)

Concurrent Symposium 11
11:00 - 12:20

Biomarkers for prediction of drug metabolism and toxicity

Ann Daly
Christopher Goldring

Ann Daly - Pharmacogenomics of drug-induced liver injury-metabolic and immunogenetic biomarkers

Christopher Goldring - Biomarkers for drug-induced liver injury and the TransBioLine study

Mikko Niemi - Circulating biomarkers for drug transporters

Concurrent Symposium 12
11:00 - 12:20

3D experimental models and organ-on-chips in drug metabolism

Volker M. Lauschke
Tore B. Stage

Volker M. Lauschke - Organotypic and microphysiological primary human tissue models for translational pharmacology

Jasleen K. Sodhi - Hepatic 3D Liver Models and IVIVE

Jonathan Sexton - Personalized Liver Injury Risk Prediction: Patient-Derived Organoids on Chip

12:20 - 13:20
Lunch, Exhibit Hall Hours

13:20 - 14:20
Poster Viewing, Poster Presentation Session

Concurrent Symposium 13
14:20 - 15:40

Inflammatory regulation of cytochrome P450 enzymes and COVID-19

Kerry B. Goralski
Tore B. Stage

Kerry B. Goralski - COVID-19 and CYP3A4 drug metabolism interactions: A review of the evidence

Tore B. Stage - Translational aspects of drug metabolism during inflammation from clinical studies and 3D primary human hepatocytes

Gülsah Gabriel - Respiratory virus infection mediated dysregulation of sex hormone metabolism

Concurrent Symposium 14
14:20 - 15:40

Omics and single-cell-based technologies in the study of drug metabolism

Albert Braeuning
Damjana Rozman

Albert Braeuning - The use of proteomic approaches to analyze in vivo effects of phenobarbital in mice with humanized livers

Damjana Rozman - Targeted omics for innovative decision support systems: examples of COVID-19 and liver cancer

Celia P. Martinez-Jimenez - Unraveling Hepatocyte Heterogeneity: Implications for Drug Metabolism and Toxicity Under Metabolic Stress

15:40 - 16:10
Coffee break (30 min)

16:10 - 16:30 Commercial presentations

Concurrent Symposium 15
16:30 - 17:50

Interactions of microbiome on drug metabolism

Pavel Anzenbacher

Hyunyoung (Young) Jeong

Pavel Anzenbacher - Drug Metabolism and Gut Microbiome

Hyunyoung (Young) Jeong - Modulation of Drug-induced Hepatotoxicity by Gut Microbial Metabolite

Sridhar Mani - Intestinal Microbial metabolites, Nuclear Receptors, and Microbial Metabolite Mimicry: An Update

Concurrent Symposium 16
16:30 - 17:50

Oligonucleotide and peptide ADME

Xiaobo Zhong
Hongbin Yu

Hongbin Yu - Perspectives on ADME of therapeutic proteins

Aiming Yu - ADME of therapeutic RNAs

Sherouk Tawfik - Triple E challenges for better efficacy of siRNA therapeutics: targeted endocytosis, endosomal escape, and exocytosis

Organ Concert in Carolinum, medieval Hall of the Charles University

Wednesday (July 10, 2024)

Plenary lecture
8:30 - 9:00

Emily E. Scott, Ph.D.
University of Michigan
Human microsomal and mitochondrial P450 interactions with substrates and redox partners

Concurrent Symposium 17
9:10 - 10:40

Intestinal and extrahepatic metabolizing enzymes in bioavailability and disposition

Xinxin Ding

Stefan Oswald

Xinxin Ding - Dissecting hepatic and extrahepatic contributions to xenobiotic metabolism using transgenic mouse models

Stefan Oswald - Clinically relevant drug metabolizing enzymes in the human intestine

Joan Z. Zuo - Intestinal carboxylesterase mediated activation of irinotecan and its impact on herb-drug interactions

Concurrent Symposium 18
9:10 - 10:40

Drug transporters and their impact on drug metabolism and disposition

Sibylle Neuhoff
Jean Terrier

Matus Sotak - Circadian regulation of transporter expression: Implications for drug disposition and translational challenges

Dirk Theile - The unequal perpetrator effects of rifampicin vs. rifabutin on P-glycoprotein and substrate drugs pharmacokinetics

Jean Terrier - Drug transporters and their impact on pharmacokinetics of direct oral anticoagulant in PBPK models

Sibylle Neuhoff/Matthew D. Harwood - PBPK modeling of endogenous biomarker to assess hepatic and renal transporter-mediated DDIs in healthy and disease

10:40 - 11:10
Coffee break (30 min)

11:10 - 12:00
Best Posters Awards and Best Poster Winner Presentations

Closing Ceremony
Closing Remarks
The upcoming 26th MDO meeting in Hong Kong

12:30 - 13:30
MATTEK Workshop

Optional Visit to Prague Castle (not incl. in the registration fee)